Top augment choices for Vayne include Deft (Silver), Twice Thrice (Gold), Dual Wield (Prismatic).
Overall
Twice Thrice
Twice ThriceEvery @ProcCadence@ attacks, your {{ Item_Keyword_OnHit }} effects trigger a second time.
Tier: S+
Pick %: 31%
Dual Wield
Dual WieldWhen you Attack, fire a bolt that deals @AttackReduction*100@% damage and applies your {{ Item_Keyword_OnHit }} effects at @OnHitMod*100@% effectiveness. Gain @AttackSpeed*100@% total Attack Speed.
Tier: S+
Pick %: 26%
Lightning Strikes
Lightning StrikesGain @TotalASValue*100@% total Attack Speed. At @Breakpoint1@ Attacks per second, deal additional magic damage {{ Item_Keyword_OnHit }}.
Shadow RunnerAfter using a dash, leap, blink, or teleport Ability or exiting Stealth, gain @spell.Augment_ShadowRunner:MSAmount@ Move Speed for @spell.Augment_ShadowRunner:BuffDuration@ seconds.
Tier: S+
Pick %: 10%
Gold
Twice Thrice
Twice ThriceEvery @ProcCadence@ attacks, your {{ Item_Keyword_OnHit }} effects trigger a second time.
Tier: S+
Pick %: 31%
Lightning Strikes
Lightning StrikesGain @TotalASValue*100@% total Attack Speed. At @Breakpoint1@ Attacks per second, deal additional magic damage {{ Item_Keyword_OnHit }}.
Tier: S+
Pick %: 24%
Firebrand
FirebrandYour Attacks apply an infinitely stacking Burn {{ Item_Keyword_OnHit }}, dealing damage over time.
Tier: S+
Pick %: 14%
Prismatic
Dual Wield
Dual WieldWhen you Attack, fire a bolt that deals @AttackReduction*100@% damage and applies your {{ Item_Keyword_OnHit }} effects at @OnHitMod*100@% effectiveness. Gain @AttackSpeed*100@% total Attack Speed.
Tier: S+
Pick %: 26%
Fan the Hammer
Fan the HammerWhen you Attack, fire @AdditionalBolts@ bolts that each deal physical damage and applies your {{ Item_Keyword_OnHit }}.
Tier: S+
Pick %: 19%
Tap Dancer
Tap DancerYour Attacks grant you @MSPerHit@ Move Speed {{ Item_Keyword_OnHit }}. Gain Attack Speed equal to @MSToASConversion*10000@% of your Move Speed.